Demolition of this Home Started to Change Attitudes #TBT

This home was intimately linked with two important individuals. During the occupancy of the latter, a plaque was mounted on the side of the house (nearly centered on the above photo) honoring the former.

After the dust had settled from the wrecking ball's demolition of the landmark, private and public efforts began to protect Lexington's historical resources. You are looking at the birthplace of Lexington's historic preservation efforts.

But what are you looking at? And who were the two individuals alluded to above?

UPDATE: Read the history of this house and the answers to the questions asked by clicking here.